Integrative in silico and Petra/Osiris/Molinspiration (POM) analysis of baicalein: identification of therapeutically relevant pharmacophores against keloid pathology
In-silico analysis suggests that baicalein may influence TGF-β receptors and exhibit anti-keloid activity. Additionally, POM analysis recommends that baicalein may serve as a lead compound with the potential to modulate TGF-β signalling and exhibit antiviral properties, indicating it as a dual-action agent against keloids and viral infections.
Authors
- Neti Waranuch (ORCID: https://orcid.org/0000-0001-7476-7288)
- Abhay Prakash Mishra (ORCID: https://orcid.org/0000-0002-2224-0852)
- Anothai Tangsumranjit (ORCID: https://orcid.org/0000-0001-7501-1052)
- Manisha Nigam (ORCID: https://orcid.org/0000-0002-2405-9790)
- Taïbi Ben Hadda (ORCID: https://orcid.org/0000-0002-5633-6203)
- Faisal A. Almalki (ORCID: https://orcid.org/0000-0003-4048-1526)
- Harish Chandra (ORCID: https://orcid.org/0000-0002-0448-0174)
Institutions
- Gurukul Kangri Vishwavidyalaya (IN)
- Hemwati Nandan Bahuguna Garhwal University (IN)
- Umm al-Qura University (SA)
- Euro-Mediterranean University of Fes (MA)
- Naresuan University (TH)
Publication Details
- Journal
- Drug Target Insights
- Published
- 2025-07-16
- DOI
- https://doi.org/10.33393/dti.2025.3574
- Citations
- 2
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79