Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma
The PCD prediction model effectively predicts prognosis in HCC patients and reveals critical insights into the tumor microenvironment and immune cell exhaustion. This study underscores the potential of PCD-related biomarkers in guiding personalized treatment strategies for HCC.
Authors
- Yi Zhang (ORCID: https://orcid.org/0000-0003-1642-5890)
- Kai Lei (ORCID: https://orcid.org/0000-0001-9085-9801)
- Jian Wu (ORCID: https://orcid.org/0000-0002-6325-0766)
- Yutong Zhao (ORCID: https://orcid.org/0000-0001-6604-9315)
- Jade M. Tan (ORCID: https://orcid.org/0000-0003-3677-7666)
- Jiawei Liu (ORCID: https://orcid.org/0000-0002-5794-1683)
- Jiehui Tan (ORCID: https://orcid.org/0000-0003-1977-8368)
- Shumin Li (ORCID: https://orcid.org/0000-0003-0802-4202)
- Wenhao Chen (ORCID: https://orcid.org/0000-0002-0626-3739)
- Qi Zhou (ORCID: https://orcid.org/0000-0002-9521-1139)
- Caihong Zhou
Institutions
- Sun Yat-sen University (CN)
- Central People's Hospital of Zhanjiang (CN)
- Nanfang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Qujiang People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1589563
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation