Investigation Of Salvadora Persica Extract's Inhibitory Activity On Specific Pathogenic Bacteria

Twelve organic extracts from Salvadora persica (S. persica) were tested for their antibacterial properties against Gram+ *Staphylococcus aureus and Gram- Escherichia coli*. Disk diffusion assays revealed dose-dependent inhibitory activity, with concentrations of 3%, 5%, and 7% (w/v) producing significant inhibition zones of 35 ± 0.5 mm and 30 ± 0.5 mm for E. coli and S. aureus, respectively. The extracts have shown superior activity against Gram- bacteria relative to Gram+ strains (p < 0.05). Comparative analysis demonstrated that the antibacterial potency of S. persica extracts either matched or exceeded that of standard antibiotics, particularly against multidrug-resistant (MDR) variants. The results underscore the potential of S. persica as a natural, cost-effective substitute for traditional antibiotics, presenting a promising solution for addressing antibiotic-resistant bacteria. Additional in vivo and experimental research are necessary to confirm these findings and identify the bioactive chemicals responsible for the reported effects.