11 <i>α</i> -hydroxydysobinin: a new limonoid from <i>Chisocheton macrophyllus</i> seeds (Meliaceae)
A new limonoid compound 11<i>α</i>-hydroxydisobinin (<b>1</b>), along with a known limonoid compound (<b>2</b>), was isolated from ethyl acetate extract of <i>Chisocheton macrophyllus</i> (Meliaceae) seeds. The structure and stereochemical configuration of compound <b>1</b> was characterized by HR-ESI-MS, UV, IR, NMR, and ECD analysis through quantum chemical calculations (TD-DFT analysis and DP4+ NMR). Both limonoids were tested for their cytotoxic activities against MCF-7 breast cancer cells with IC<sub>50</sub> values of 112.5 and 51.7 µM.
Authors
- Kindi Farabi (ORCID: https://orcid.org/0000-0001-5552-3827)
- Unang Supratman (ORCID: https://orcid.org/0000-0003-1104-2321)
- Rani Maharani (ORCID: https://orcid.org/0000-0002-4832-7227)
- Desi Harneti (ORCID: https://orcid.org/0000-0002-8120-7892)
- Tri Mayanti (ORCID: https://orcid.org/0000-0003-1628-6288)
- Wahyu Safriansyah (ORCID: https://orcid.org/0000-0002-3243-4001)
- Muhammad Badrul Huda
- Lulu Wilden Azzahra
Institutions
- Diponegoro University (ID)
- Padjadjaran University (ID)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1080/10286020.2025.2525332
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00