Amino acid intake, plasma metabolites, and incident type 2 diabetes risk: a systematic approach in prospective cohort studies
This study provides novel evidence that higher intake of sulfur and aromatic AAs is independently associated with an increased risk of T2D. Multiple plasma metabolites are responsive to these dietary AAs, potentially serving as objective markers for AA intake. Collectively, the metabolite signatures significantly predict a higher T2D risk, and mediate the positive associations to various degrees, corroborating findings from long-term dietary assessments.
Authors
- A. Heather Eliassen (ORCID: https://orcid.org/0000-0002-3961-6609)
- Qi Sun (ORCID: https://orcid.org/0000-0002-8480-1563)
- Oana A. Zeleznik (ORCID: https://orcid.org/0000-0002-8705-1163)
- Siyue Wang (ORCID: https://orcid.org/0000-0002-0186-7955)
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Μolin Wang (ORCID: https://orcid.org/0000-0002-9150-7928)
- Jeffrey Yuan (ORCID: https://orcid.org/0000-0003-3855-1994)
- Yang Hu (ORCID: https://orcid.org/0000-0002-0200-5951)
- Yanping Li (ORCID: https://orcid.org/0000-0002-0412-2748)
- Frank B. Hu
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Nutrition Journal
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12937-025-01157-x
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Institutes of Health