Qingrehuoxue formula enhances anti-PD-1 immunotherapy in NSCLC by remodeling the tumor immune microenvironment via TREM2 signaling
QRHXF enhanced antitumor immune responses in NSCLC via TREM2 and modulation of the PI3K/AKT/STAT6 signaling pathway, reducing chemotactic infiltration of M2 tumor-associated macrophages within the TME. This suggests its potential as an adjuvant immune therapy for improved patient outcomes.
Authors
- Yawei Jiang (ORCID: https://orcid.org/0000-0003-3125-3732)
- Minmin Yu (ORCID: https://orcid.org/0000-0001-5076-6934)
- Jiachen Zang (ORCID: https://orcid.org/0000-0003-0566-9726)
- Qian Meng (ORCID: https://orcid.org/0000-0002-2149-1086)
- Fei Xu (ORCID: https://orcid.org/0000-0002-6438-3464)
- Xue Li (ORCID: https://orcid.org/0000-0002-9523-869X)
- Binbin Li (ORCID: https://orcid.org/0000-0002-8572-8003)
- Danni Wang (ORCID: https://orcid.org/0000-0002-1071-0888)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12906-025-05020-8
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- China Postdoctoral Science Foundation
- Taishan Scholar Project of Shandong Province
- Shandong Provincial Postdoctoral Science Foundation