Effect of IL-1β on NSCLC-Derived Small Extracellular Vesicles as Actors in Mediating Cancer Progression and Evading Immune System
Our findings indicate that TEVs promote EMT in NSCLC cells by the activation of the fibronectin-α5β1 axis. Finally, IL-1β stimulation induces TEV release with biological properties similar to OR TEVs, thus leading to cancer invasion and immune suppression and suggesting that inflammation can promote tumor spreading.
Authors
- Giovanni Nicola Roviello (ORCID: https://orcid.org/0000-0002-6978-542X)
- Adriano Piattelli (ORCID: https://orcid.org/0000-0002-6246-8130)
- Francesca Iommelli (ORCID: https://orcid.org/0000-0002-5132-3593)
- Floriana Morgillo (ORCID: https://orcid.org/0000-0002-9167-323X)
- Concetta Tuccillo (ORCID: https://orcid.org/0000-0001-8713-2169)
- Giuseppe De Rosa (ORCID: https://orcid.org/0000-0002-1210-1269)
- Paola Franco (ORCID: https://orcid.org/0000-0002-3289-7284)
- Rosa Camerlingo (ORCID: https://orcid.org/0000-0001-6488-9740)
- Natalia Di Pietro (ORCID: https://orcid.org/0000-0001-9720-2116)
- Maria Patrizia Stoppelli (ORCID: https://orcid.org/0000-0003-2402-1087)
- Carminia M. Della Corte (ORCID: https://orcid.org/0000-0002-3396-8099)
- Giovanni Vicidomini (ORCID: https://orcid.org/0000-0002-1002-6090)
- Viviana De Rosa (ORCID: https://orcid.org/0000-0002-0430-5608)
- Hamid Heydari Sheikh Hossein (ORCID: https://orcid.org/0000-0002-3289-4219)
- Daniela Omodei (ORCID: https://orcid.org/0000-0001-8710-2971)
- Valeria Nele
- Annalisa Ariano
- Caterina De Rosa (ORCID: https://orcid.org/0000-0001-6540-0708)
- Luisa Amato (ORCID: https://orcid.org/0009-0005-6511-8071)
- Sabrina Critelli
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- University of Chieti-Pescara (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Institute of Biostructure and Bioimaging (IT)
- Institute of Genetics and Biophysics (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- National Research Council (IT)
- Universidad Católica de Murcia (ES)
- University of Naples Federico II (IT)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3390/ijms26146825
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- European Commission
- Associazione Italiana per la Ricerca sul Cancro
- Fondazione Italiana per la Ricerca sul Cancro