SDMA (Synhydrid, Red-Al, Vitride): A Chemoselective and Safe Solution for Reduction Reactions

Discovered in 1965, SDMA has become a key reducing agent in organic synthesis, known for its selectivity, stability, and improved safety over traditional hydrides such as lithium aluminum hydride (LiAlH4, LAH) and diisobutylaluminum hydride (DIBAL-H). It enables efficient reductions, including selective and partial reductions, in both academic and industrial settings. This review explores its diverse applications, highlights its advantages, and provides detailed insights into the various workup procedures associated with its use.