Mexicanolide limonoids from <i>Khaya ivorensis</i> with anti-hyaluronidase activities
Phytochemical study on 80% methanol extract from the seeds of <i>Khaya ivorensis</i> resulted into the isolation of three undescribed mexicanolide limonoids, ivorensisines A-C (<b>1</b>-<b>3</b>). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated <i>in vitro</i> for anti-hyaluronidase activities. As a result, limonoid <b>3</b> exhibited significant anti-hyaluronidase activity (IC<sub>50</sub> = 8.46 μg/ml) three times more than the positive control drug oleanolic acid (IC<sub>50</sub> = 39.98 μg/ml).
Authors
- Meng Shi (ORCID: https://orcid.org/0000-0002-5412-7977)
- F. Liu (ORCID: https://orcid.org/0009-0006-7718-0742)
- Yang Chen (ORCID: https://orcid.org/0000-0002-3244-5384)
- Hang Jie (ORCID: https://orcid.org/0000-0003-3491-8971)
- Ai-Yong He
- Xu Zeng
- Fei Zhu (ORCID: https://orcid.org/0000-0002-9122-1161)
- X Ren
Institutions
- Shaoxing University (CN)
- Shanghai Changzheng Hospital (CN)
- Maternity and Children's Hospital (SA)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1080/10286020.2025.2526828
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00