The diagnostic potential of unconjugated bilirubin in schizophrenia and bipolar disorder
This study found that patients with schizophrenia had significantly higher unconjugated bilirubin levels compared to patients with bipolar disorder. Mendelian randomization results suggest a positive causal relationship between unconjugated bilirubin and schizophrenia. Decreases in unconjugated bilirubin after MECT alleviated clinical symptoms of schizophrenia. It provides a new idea for clinical diagnosis of schizophrenia and bipolar disorder.
Authors
- Huang-Hui Liu
- Yao Gao (ORCID: https://orcid.org/0000-0003-4722-5066)
- Bingbing Chen (ORCID: https://orcid.org/0000-0001-5995-4464)
- Yong Xu (ORCID: https://orcid.org/0000-0001-9679-2273)
- Sha Liu (ORCID: https://orcid.org/0000-0002-6710-8126)
- Si-Meng Wei
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12888-025-07143-1
- Citations
- 1
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Natural Science Foundation of Shenzhen City
- Health Commission of Shanxi Province
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanxi Scholarship Council of China
- Natural Science Foundation of Shanxi Province
- Shanxi Medical University
- National Key Research and Development Program of China