Chemical constituents from the fibrous roots of <i>Anemarrhena asphodeloides</i> and their <i>in vitro</i> cytotoxic activity
To explore chemical constituents in the fibrous roots of <i>Anemarrhena asphodeloides</i>, 12 compounds were obtained, including three undescribed compounds <b>(1-3)</b> and nine known related compounds <b>(4-12)</b>. Their structures were determined by spectroscopic analyses, including 1D, 2D NMR, and HRESIMS data. The cytotoxic activity of all isolates was evaluated against two human hepatoma carcinoma cells (HepG2 and Hep3B) <i>in vitro</i>. Among them, compounds <b>1</b>, <b>2,</b> and <b>4</b> exhibited inhibitory effects at high concentration of 50 μM. Compound <b>4</b> showed cytotoxic activities against HepG2 and Hep3B cell lines with the IC<sub>50</sub> values of 14.80 ± 0.58 and 10.89 ± 0.46 μM, respectively.
Authors
- Deling Wu (ORCID: https://orcid.org/0000-0001-6027-0625)
- Zhen-Dong Liao
- Hongsu Zhao
- Qi Huang (ORCID: https://orcid.org/0000-0002-3650-5786)
- Rui Sun (ORCID: https://orcid.org/0000-0002-7307-5869)
- Feng-Qing Xu (ORCID: https://orcid.org/0000-0002-3158-2432)
- Renzhong Wang (ORCID: https://orcid.org/0000-0001-8968-387X)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Key Laboratory of Guangdong Province (CN)
- Xian Yang Central Hospital (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1080/10286020.2025.2529993
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.00