Switching from controlled to assisted mechanical ventilation: a multi-center retrospective study (SWITCH)
Approximately two-thirds of attempts to switch patients to assisted ventilation fail, which are associated with significantly worse clinical outcomes, despite similar baseline disease severity. Contrary to our hypotheses, patients with successful and failed attempts showed similar characteristics, making switch failure difficult to predict. These findings underscore the importance of preventing switch failures and, given the retrospective nature of this study, highlight the need for prospective studies to better understand the reasons for switch failure and when spontaneous breathing can be safely initiated.
Authors
- Marcel J. T. Reinders (ORCID: https://orcid.org/0000-0002-1148-1562)
- Jasper van Bommel (ORCID: https://orcid.org/0000-0001-8408-0500)
- Jim M Smit (ORCID: https://orcid.org/0000-0003-3716-1863)
- Michel E. van Genderen (ORCID: https://orcid.org/0000-0001-5668-3435)
- Annemijn H. Jonkman (ORCID: https://orcid.org/0000-0001-8778-5135)
- Jesse H. Krijthe (ORCID: https://orcid.org/0000-0003-3435-6358)
- Diederik A. M. P. J. Gommers
Institutions
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s40635-025-00785-1
- Citations
- 4
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Erasmus Universitair Medisch Centrum Rotterdam