Study of the proliferative activity of the spleen under conditions of burn injury of the skin

The article describes the results of studying the proliferative activity of the spleen under conditions of burn injury. The study was carried out on non-linear male rats with an average weight of 220 grams. Age 4–6 months. Laboratory animals were divided into 7 groups of 10 individuals each. Group 1 (control) included intact animals that did not undergo burn exposure. 2–7 experimental groups were laboratory animals exposed to burns and removed from the experiment on the 2-, 4-, 7-, 10-, 14-, 21st day after the burn, respectively. In all experimental groups, contact burn injury was simulated in the depilated interscapular region of the back under ether narcotic conditions. By affecting the skin, the burn injury triggers a cascade of sequential reactions at the level of the whole organism. In conditions of endotoxicosis developing during burns, the spleen is central to the restoration and preservation of homeostasis. During the study, it was found that in the dynamics of the postburn process of the skin in the spleen, there was a decrease in proliferative processes, which indicated a systemic effect of burn injury. Taking into account the results of the study, it can be concluded that in the early period (2-4 days) of burn exposure in the spleen, a noticeable decrease in the proliferative activity of spleen cells was noted, indicating inhibition of the functional activity of the immune organ. After 14 days, the proliferative potential was gradually restored.