Pulmonary Hypertension Secondary to Fungal Infections: Underexplored Pathological Links
This narrative mini-review explores three key mechanisms underlying vascular remodeling in this context: (1) endothelial injury caused by fungal emboli or autoimmune reactions, (2) direct vascular remodeling during chronic infection driven by inflammation and fibrosis, and (3) distant vascular remodeling post-infection, as seen in granulomatous diseases like paracoccidioidomycosis. Further research and clinical screening for pulmonary hypertension in fungal infections are crucial to improving patient outcomes.
Authors
- Carlos Mario González-Zambrano (ORCID: https://orcid.org/0000-0002-6840-0460)
- Luciane Alarcão Dias‐Melicio (ORCID: https://orcid.org/0000-0001-9254-2074)
- Alfonso Rodríguez‐Herrera (ORCID: https://orcid.org/0000-0002-1155-280X)
- Sabrina Setembre Batah (ORCID: https://orcid.org/0000-0002-9694-3489)
- Alexandre Todorovic Fabro (ORCID: https://orcid.org/0000-0002-7687-3161)
- Maria Júlia Faci Do Marco
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Clinics Hospital of Ribeirão Preto (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Infectious Disease Reports
- Published
- 2025-07-12
- DOI
- https://doi.org/10.3390/idr17040084
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo