Synthesis of N-formyl dihydropyrazoles as urease inhibitors
Abstract In this study dihydropyrazole based derivatives were synthesized from substituted chalcone through Michael addition reaction. Urease inhibition activity of the compounds was evaluated, revealing that most compounds exhibited moderate inhibition. Among the synthesized compounds, 2b, 2m, and 2n demonstrated exceptional potency with IC 50 values of 5.21 ± 0.91 µM, 6.21 ± 0.10 µM, and 5.21 ± 0.81 µM, respectively. Thus, these findings suggest that dihydropyrazole represent a promising scaffold for the development of novel urease inhibitors.
Authors
- Wajid Ur Rehman (ORCID: https://orcid.org/0000-0003-0128-0377)
- Obaid‐ur‐Rahman Abid (ORCID: https://orcid.org/0000-0002-3553-6089)
- Liaqat Rasheed (ORCID: https://orcid.org/0000-0003-3602-6803)
- Ashwag S. Alanazi (ORCID: https://orcid.org/0000-0003-1042-8126)
- Mohammed M. Alanazi (ORCID: https://orcid.org/0000-0002-0483-8113)
- Naveed Iqbal
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Hazara University (PK)
- King Saud University (SA)
- Henan University of Technology (CN)
Publication Details
- Journal
- Pure and Applied Chemistry
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1515/pac-2025-0425
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Princess Nourah Bint Abdulrahman University