Spontaneously Regressing Penile Extramammary Paget Disease without Recurrence of Primary Urothelial Carcinoma: A Case Report.

Secondary EMPD can present without underlying malignancy and may spontaneously regress. This is a rare phenomenon and the mechanism is not yet known. We speculate that it may be related to adaptive immunity, local inflammation promoted by biopsy and that there was no underlying primary malignancy. Treatment decisions should be made in the context of thorough goals of care discussions. Further observation of this phenomenon is required to guide management plans.