Brain and CSF Alzheimer’s Biomarkers Are Associated with SERPINE1 Gene Expression
CSF SERPINE1 levels can be used as an early biomarker for the detection of pathological changes associated with AD. Higher SERPINE1 levels correlate more strongly with tau pathology than with amyloid formation or deposition.
Authors
- Judes Poirier (ORCID: https://orcid.org/0000-0002-8018-4545)
- Cynthia Picard (ORCID: https://orcid.org/0000-0003-1107-6839)
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- University of Wisconsin–Madison (US)
- Douglas Mental Health University Institute (CA)
- Sahlgrenska University Hospital (SE)
- German Center for Neurodegenerative Diseases (DE)
- Center for Diagnosis and Research on Alzheimer's Disease (CA)
- Institute for Neurodegenerative Disorders (US)
- UK Dementia Research Institute (GB)
- University College London (GB)
- McGill University (CA)
- Indian Institute of Science Bangalore (IN)
- University of Gothenburg (SE)
Publication Details
- Journal
- Genes
- Published
- 2025-07-12
- DOI
- https://doi.org/10.3390/genes16070818
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00