Hypothermic Machine Perfusion Is Associated with Improved Short-Term Outcomes in Liver Transplantation: A Retrospective Cohort Study
The study underscores the effectiveness of hypothermic machine perfusion (HMP) as a superior preservation method compared to traditional static cold storage (SCS), HMP appears to be associated with improved short-term outcomes in liver transplantation. By substantially reducing postoperative complications and enhancing graft viability, HMP emerges as a pivotal strategy for maximizing the use of marginal donor organs. Further research and broader clinical implementation are recommended to validate these promising results and to fully harness the potential of HMP in liver transplantation.
Authors
- Irina Gîrleanu (ORCID: https://orcid.org/0000-0001-5925-1232)
- Nutu Vlad
- Ramona Cadar
- Corina Lupașcu Ursulescu (ORCID: https://orcid.org/0000-0002-7539-9453)
- Alexandru Năstase (ORCID: https://orcid.org/0009-0003-1032-608X)
- Ana-Maria Trofin (ORCID: https://orcid.org/0000-0003-3870-2692)
- Cristina Muzîca (ORCID: https://orcid.org/0000-0003-0891-5961)
- Mihai Zabara (ORCID: https://orcid.org/0000-0001-9260-6322)
- Bogdan Mihnea Ciuntu (ORCID: https://orcid.org/0000-0001-7911-0699)
- Ciprian Vasiluţă
- Iulian Buzincu (ORCID: https://orcid.org/0000-0001-6724-2029)
- A Vasilescu (ORCID: https://orcid.org/0000-0002-9865-5114)
- Cristian Lupaşcu (ORCID: https://orcid.org/0000-0003-1522-5766)
- Florin Iftimie
Institutions
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi (RO)
Publication Details
- Journal
- Life
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3390/life15071112
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00