Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study
Our findings reveal a novel pathogenic role of sirtuin-5 in hypopharyngeal cancer, suggesting its potential as a therapeutic target. Conversely, laryngeal cancer might slightly affect transferrin saturation and ETHE1, indicating their utility as diagnostic markers for laryngeal cancer. Future mechanistic studies are warranted to elucidate these complex associations.
Authors
- Jiandong Zhao (ORCID: https://orcid.org/0000-0001-8402-0380)
- Ge Gao (ORCID: https://orcid.org/0000-0001-6470-8815)
- Siyang Li (ORCID: https://orcid.org/0009-0009-0103-0141)
- Yongxia Zhang (ORCID: https://orcid.org/0000-0001-9342-263X)
- Bing Han (ORCID: https://orcid.org/0000-0001-7600-6693)
- Jinjing Liu (ORCID: https://orcid.org/0000-0003-2150-7540)
- Liwei Chen (ORCID: https://orcid.org/0000-0003-4160-9771)
Institutions
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1007/s12672-025-03187-7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00