2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic <i>Histoplasma</i> Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Ch
As the first part of an update to the clinical practice guideline on the management of histoplasmosis in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, we present 4 updated recommendations. These recommendations span treatment of asymptomatic Histoplasma pulmonary nodules (histoplasmomas), mild acute pulmonary histoplasmosis, and moderate acute pulmonary histoplasmosis. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.
Authors
- Karen C. Bloch (ORCID: https://orcid.org/0009-0000-8491-8246)
- Sandra R. Arnold (ORCID: https://orcid.org/0000-0001-6130-8154)
- Kayla R. Stover (ORCID: https://orcid.org/0000-0002-8635-0137)
- Nevert Badreldin (ORCID: https://orcid.org/0000-0002-6341-3350)
- Andrej Spec (ORCID: https://orcid.org/0000-0001-7612-4710)
- Michael Saccente (ORCID: https://orcid.org/0000-0003-3595-2274)
- Monica I. Ardura (ORCID: https://orcid.org/0000-0002-2853-2581)
- Nathan C. Bahr (ORCID: https://orcid.org/0000-0002-9431-8938)
- Rachel Miller (ORCID: https://orcid.org/0000-0001-7387-1171)
- John W. Baddley (ORCID: https://orcid.org/0000-0001-9111-625X)
- Robert J. Lentz (ORCID: https://orcid.org/0000-0002-8186-0832)
- Peter J. Pappas (ORCID: https://orcid.org/0000-0002-7219-8242)
- Ilan S. Schwartz (ORCID: https://orcid.org/0000-0002-7522-0281)
- Nathan P. Wiederhold (ORCID: https://orcid.org/0000-0002-2225-5122)
- Joshua Wolf (ORCID: https://orcid.org/0000-0002-9912-3646)
- Carol A. Kauffman
- Jennifer Loveless
- Satish Mocherla
Institutions
- Northwestern University (US)
- University of Minnesota (US)
- St. Jude Children's Research Hospital (US)
- Nationwide Children's Hospital (US)
- Johns Hopkins University (US)
- University of Tennessee Health Science Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- Duke University (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- Infectious Diseases Society of America (US)
- Johns Hopkins Medicine (US)
- University of Alabama at Birmingham (US)
- University of Mississippi (US)
- Methodist Hospital (US)
- University of Kansas Medical Center (US)
- Le Bonheur Children's Hospital (US)
- The Ohio State University (US)
- University of Arkansas for Medical Sciences (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1093/cid/ciaf256
- Citations
- 11
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 14.90
Funders
- Infectious Diseases Society of America
- Cidara Therapeutics
- Astellas Pharma