ASSOCIATION OF LIPID PROFILE WITH CHOLESTEROSIS IN CHOLELITHIASIS PATIENTS - A HOSPITAL-BASED STUDY

The objective was to evaluate the prevalence of cholesterosis in cholelithiasis patients in semi urban population and to analyse various biochemical parameters of lipid profile in cholelithiasis patients and find its association and correlation with cholesterosis in cholelithiasis patients. Materials and methods: Prospective study was carried out on 200 patients of cholelithiasis admitted in hospital. Based on the histopathological examination done, patient was grouped in two groups cholelithiasis with cholesterosis and without cholesterosis. Various parameters of lipid profile were studied in both the groups and association with cholelithiasis was analysed. Statistical analysis: Data were methodically gathered and assembled and these observations were tabulated. Mean values of the variables were tested against normal ranges. A separate t-test was applied which showed p<0.05 which was considered statistically significant. Data was analysed using IBM SPSS statistics for windows version 29. Results: out of 200 cholelithiasis patients 57 patients were having cholesterosis (47 were females and 10 were males) and rest 143 was having cholelithiasis without cholesterosis. Females were predominant in both the groups. Among the biochemical parameters, Total cholesterol, TG, LDL, VLDL, TC/HDL levels were significantly increased in subjects having cholelithiasis with cholesterosis as compared to cholelithiasis without cholesterosis. Moreover, HDL and HDL/LDL levels were decreased significantly in subjects having cholelithiasis with cholesterosis compared to cholelithiasis without cholesterosis. Conclusion: The relationship between lipid profile and cholesterosis in cholelithiasis patients conclude that derangement in lipid profile is risk factor of cholesterosis in cholelithiasis patients. Early detection of deranged lipid profile will help in earlier diagnosis of cholesterosis and its management.