Unique Role of Intracellular Perinuclear β <sub>1</sub> -Adrenergic Receptors in Defining Signaling Compartmentation and Pathological Cardiac Remodeling
These results demonstrate that β<sub>1</sub>ARs localized to Golgi membranes facing the outer nuclear membrane regulate A-kinase anchoring protein 6β signalosomes required for the induction of pathological cardiac remodeling, defining an intracellular nanocompartment. Proof of concept is provided for a novel therapeutic approach for familial dilated cardiomyopathy, with potential application to other forms of cardiovascular disease.
Authors
- Kimberly L. Dodge‐Kafka (ORCID: https://orcid.org/0000-0003-0500-5698)
- Michael S. Kapiloff (ORCID: https://orcid.org/0000-0002-7005-6953)
- Anne‐Maj Samuelsson (ORCID: https://orcid.org/0000-0002-6317-2016)
- Zhuyun Qin (ORCID: https://orcid.org/0000-0002-9521-1083)
- Moriah Gildart Turcotte (ORCID: https://orcid.org/0000-0002-4622-2720)
- Jinliang Li (ORCID: https://orcid.org/0000-0002-3018-0570)
- Sofia M. Possidento (ORCID: https://orcid.org/0009-0004-3999-5583)
Institutions
- Cardiovascular Institute of the South (US)
- UConn Health (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1161/circulationaha.124.072682
- Citations
- 3
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.42