PPARγ Agonists Accelerate MRI Signal Resolution Mediated by Resting-State Astroglia in Acute Intracerebral Hemorrhage
Combined treatment with the calcium channel blocker, pyr3, and the PPARγ agonist accelerated the early absorption of heme iron by resting-state astrocytes, leading to improved functional performance and reduced edema in later stages.
Authors
- Cheng‐Di Chiu (ORCID: https://orcid.org/0000-0003-0369-0935)
- Yi‐Chin Yang (ORCID: https://orcid.org/0000-0002-9651-3761)
- You-Pen Chiu (ORCID: https://orcid.org/0000-0002-6099-7987)
- Dennis W. Hwang (ORCID: https://orcid.org/0000-0001-9974-4728)
- Hui-Ru Ji (ORCID: https://orcid.org/0000-0003-4478-7389)
- Chuchu Shen
Institutions
- China Medical University (TW)
- Taichung Veterans General Hospital (TW)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- China Medical University Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Stroke
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1161/strokeaha.124.048584
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00