Scalable and Continuous Generation of Plasma-Treated Solutions Designed for Healthcare Applications

The clinical application of physical-plasma-treated solutions (PTS) within the human body has become increasingly encouraging for many intracorporal disorders where the expected effectiveness of direct plasma application is opposed by limited accessibility. In order to increase the likelihood of intracorporal application of PTS, the interaction of more sophisticated technologies and materials is urgently required to optimize the scalable, sterile, and continuous transfer of biologically reactive species (reactive oxygen and nitrogen species, RONS) into liquids. In this study, we present an innovative fluidic system characterized by the separation of plasma discharge and liquid by a semipermeable membrane to achieve these goals. In addition to the in-depth characterization of membrane–plasma interactions and RONS transfer to different solutions, the biomedical efficacy of the generated PTS was investigated in vitro. Our findings demonstrate the functionality of a transmembraneous RONS transport using a semipermeable membrane and the potential of the system to treat tumors within the human body.