Constructing a Preeclampsia Organoid Model to Elucidate the Mechanism of Aspirin
This study clarifies aspirin's multitarget mechanisms in alleviating preeclampsia, which include restoring the sFLT-1/PlGF balance, activating the PI3K-AKT-mTOR signaling pathway, optimizing mitochondrial function, and regulating CYP-mediated hormonal metabolism. These findings provide a mechanistic basis for aspirin's clinical effectiveness in preventing preeclampsia.
Authors
- Shengbo Huang (ORCID: https://orcid.org/0009-0004-3814-1375)
- Yujia Yang (ORCID: https://orcid.org/0000-0002-9130-7619)
- Luping Zhao (ORCID: https://orcid.org/0000-0002-9439-8683)
- Bingyi Yao
- Chenmeizi Liang
- Xin Wang (ORCID: https://orcid.org/0000-0001-8079-8638)
- Yuanjin Zhang (ORCID: https://orcid.org/0000-0001-7103-2059)
- Xin Xu
- Junze Huang
- Yuanqing Guo (ORCID: https://orcid.org/0000-0002-4518-6342)
- Yifei Shen (ORCID: https://orcid.org/0000-0001-7174-4793)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-6223-4724)
- Qifan Qi
Institutions
- Shanghai Changning Maternity and Infant Health Hospital (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25342
- Citations
- 5
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 10.29