PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations
PIEZO1 expression and signaling are elevated in type 2 hereditary hemorrhagic telangiectasia. PIEZO1 blockade reduces AVM formation and alleviates cellular and molecular hallmarks of ALK1-deficient cells. This finding provides new insights into the mechanistic underpinnings of ALK1-related vascular diseases and identifies potential therapeutic targets to prevent AVMs.
Authors
- Lawrence H. Young (ORCID: https://orcid.org/0000-0003-0295-7298)
- Anne Eichmann (ORCID: https://orcid.org/0000-0001-5563-210X)
- Richard J. Antaya (ORCID: https://orcid.org/0000-0001-8557-5986)
- Mark E. Robinson (ORCID: https://orcid.org/0000-0003-2363-6047)
- Hyojin Park (ORCID: https://orcid.org/0000-0002-3671-8618)
- Jessica Furtado (ORCID: https://orcid.org/0000-0002-7975-2592)
- Young‐Kwon Hong (ORCID: https://orcid.org/0000-0001-8245-875X)
- Sungwoon Lee (ORCID: https://orcid.org/0000-0002-8019-8867)
- Martin Alexander Schwartz (ORCID: https://orcid.org/0000-0002-2071-1243)
- S. Paul Oh
Institutions
- University of Southern California (US)
- Barrow Neurological Institute (US)
- Inserm (FR)
- Yale Cancer Center (US)
- Yale University (US)
- USC Norris Comprehensive Cancer Center (US)
- Paris Cardiovascular Research Center (FR)
Publication Details
- Journal
- Circulation
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1161/circulationaha.124.073630
- Citations
- 4
- Primary Topic
- Vascular Anomalies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.50