Role Of Pseudomonas Aeruginosa In Nosocomial Infection And Its Prevalence And Antibiotic Susceptibility Pattern

Within the Pseudomonas genus, P. aeruginosa is the most commonly linked to human infections. This bacterium is known as an opportunistic pathogen, mainly responsible for hospital-acquired infections in patients with weakened immune systems. Pseudomonas aeruginosa is a metabolically adaptable organism that can lead to a variety of severe opportunistic infections in individuals with impaired natural defenses and serious pre-existing health conditions. These infections provoke a strong neutrophilic response, resulting in considerable harm to host tissues and often show resistance to antibiotics, contributing to patient mortality. The treatment of ongoing infections is further complicated by the bacterium's capacity for adaptive resistance, influenced by its growth state within the patient, including its ability to develop as a biofilm. A range of virulence factors produced by P. aeruginosa undermine host defenses and can either directly injure host tissues or enhance the bacterium's ability to compete. Each year, the challenges in treating infectious diseases become increasingly difficult. Considering the seriousness of P. aeruginosa infections and the limited options for antimicrobial treatment, exploring alternative prevention and treatment approaches is an urgent necessity. The fact that Pseudomonas aeruginosa is a primary contributor to human illness, particularly among hospitalized patients, coupled with the scarcity of information on the prevalent strains responsible for different infections in this region of Rajasthan, motivated us to conduct this study. The research was carried out from June 2024 to December 2024 at a Tertiary care hospital in the Hadoti region of Rajasthan to assess the prevalence and antibiotic susceptibility patterns of P. aeruginosa.