Improving the Response of High-Grade Glioma (HGG) Cells to Temozolomide Treatment Through Combination With Imatinib
TMZ and IMT demonstrated cytotoxic effects in both monotherapy and combination therapy. Dual therapy yielded predominantly synergistic and additive effects, with subadditive results in approximately one-third of the combinations. Overall, combination therapy produced a better cytotoxic behavior than its individual effects in an in vitro setting.
Authors
- Alexandra Costachi (ORCID: https://orcid.org/0000-0001-8433-4072)
- Ştefana Oana Popescu
- Edmond Nicolae Barcan (ORCID: https://orcid.org/0000-0002-2744-5638)
- Daniela Elise Tache (ORCID: https://orcid.org/0000-0001-9083-5367)
- Georgiana-Adeline Staicu (ORCID: https://orcid.org/0009-0003-7522-0702)
- Ştefan-Alexandru Artene (ORCID: https://orcid.org/0000-0002-0026-3818)
- Anica Dricu (ORCID: https://orcid.org/0000-0002-3039-857X)
- Andreea Denisa Hodorog
Institutions
- Carol Davila University of Medicine and Pharmacy (RO)
- University of Medicine and Pharmacy of Craiova (RO)
- Mirai Hospital (JP)
- Institute for Nuclear Research Pitesti (RO)
- University of Craiova (RO)
Publication Details
- Journal
- Cureus
- Published
- 2025-07-16
- DOI
- https://doi.org/10.7759/cureus.88055
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii