Utilization of dexrazoxane in patients treated with doxorubicin: a retrospective, propensity matched analysis of cardiac function and toxicity

The addition of DZR to DOX did not result in a statistically significant change in EF during the treatment window. Given the limitations of the dataset, this may suggest a lack of substantial immediate benefit from the co-administration of DZR with DOX. An increased rate of high-grade neutropenia and anemia was observed in patients receiving the combination, although this may be due to confounding factors. Further analysis is warranted, ideally through larger multi-institutional or prospective studies.