Disruption of hindgut microbiome homeostasis promotes postpartum energy metabolism disorders in dairy ruminants by inhibiting acetate-mediated hepatic AMPK-PPARA axis
This study demonstrates that key gut microbes and their metabolic product (acetate) inhibit the occurrence of metabolic disorders through the hepatic AMPK-PPARA axis. These findings provide new insights and potential therapeutic targets for understanding and mitigating postpartum metabolic disorders in dairy ruminants. Video Abstract.
Authors
- Shuo Wang (ORCID: https://orcid.org/0000-0003-0225-0612)
- Dongwen Dai (ORCID: https://orcid.org/0000-0003-2252-2662)
- Zhijun Cao (ORCID: https://orcid.org/0000-0002-5519-9462)
- Xinyue Zhang (ORCID: https://orcid.org/0000-0001-6093-6335)
- Chen Li (ORCID: https://orcid.org/0000-0001-6110-3714)
- Wei Wang (ORCID: https://orcid.org/0000-0002-9138-9052)
- Shengli Li (ORCID: https://orcid.org/0000-0002-8494-7474)
- Fanlin Kong (ORCID: https://orcid.org/0000-0001-8099-0398)
- Yajing Wang (ORCID: https://orcid.org/0000-0003-4744-5106)
Institutions
- Jiangsu Academy of Agricultural Sciences (CN)
- State Key Laboratory of Animal Nutrition
- China Agricultural University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s40168-025-02150-6
- Citations
- 8
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China