Calcium ion-binding genes can predict tumor mutation burden and immune checkpoint blockade response in a pan-cancer model
These findings establish a novel association between calcium ion-binding genes and TMB, demonstrating the feasibility of a pan-cancer TMB estimation model based on calcium ion-binding genes. This approach may enhance TMB estimation and improve ICB response prediction across multiple cancers.
Authors
- Chien-Jung Huang (ORCID: https://orcid.org/0000-0003-4233-4677)
- Wan‐Yu Lin (ORCID: https://orcid.org/0000-0002-3385-4702)
- Yu‐Chao Wang (ORCID: https://orcid.org/0000-0002-1574-1691)
Institutions
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1007/s12672-025-03184-w
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Educational Development Foundation
- National Science and Technology Council