Evaluating sex-specific prediction models for colorectal cancer risk using a genome-wide polygenic risk score and lifestyle factors in a Japanese population
This study suggests that the CRC risk prediction model utilizing genome-wide PRS for Asians is valuable; however, further improvement is needed before clinical implementation.
Authors
- Motoki Iwasaki (ORCID: https://orcid.org/0000-0003-3319-4131)
- Atsushi Shimizu (ORCID: https://orcid.org/0000-0001-8307-2461)
- Aya Kuchiba (ORCID: https://orcid.org/0000-0002-6786-3527)
- Tsuyoshi Hachiya (ORCID: https://orcid.org/0000-0002-5274-3266)
- Shoichiro Tsugane (ORCID: https://orcid.org/0000-0003-4105-2774)
- Taiki Yamaji (ORCID: https://orcid.org/0000-0002-4799-8782)
- Shiori Nakano (ORCID: https://orcid.org/0000-0001-5762-850X)
- Norie Sawada (ORCID: https://orcid.org/0000-0002-9936-1476)
- Manami Inoue (ORCID: https://orcid.org/0000-0003-1276-2398)
Institutions
- Iwate Medical University (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- National Cancer Centre Japan (JP)
- National Cancer Center (US)
- National Cancer Research Institute (GB)
Publication Details
- Journal
- Cancer Epidemiology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.canep.2025.102878
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00