First-trimester triglyceride-glucose index and birth weight: a retrospective cohort mediation analysis of preterm birth and gestational complications
Our findings highlight a significant association between the first-trimester TyG index and LBW with preterm birth emerging as the primary mediating pathway and gestational complications contributing partially to this relationship. Future research should explore whether interventions aimed at preventing preterm birth and gestational complications can mitigate the LBW risk.
Authors
- Zeying Cui
- Fei Huang
- Liuzhang Ouyang (ORCID: https://orcid.org/0000-0003-2392-2801)
- Ping Li (ORCID: https://orcid.org/0000-0001-6048-181X)
- Xinyuan Chen (ORCID: https://orcid.org/0009-0000-9972-0988)
- Jinhui Cui (ORCID: https://orcid.org/0000-0003-0172-8709)
- Min Xie (ORCID: https://orcid.org/0000-0002-1338-0044)
- Hui Jiang (ORCID: https://orcid.org/0000-0002-1475-1222)
- Yanling Wang (ORCID: https://orcid.org/0000-0002-8589-4239)
Institutions
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Chinese Academy of Sciences (CN)
- Longgang Central Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12884-025-07885-6
- Citations
- 3
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province