Development and validation of the VAE-NT index: a novel biomechanical parameter for distinguishing subclinical corneal abnormalities
The VAE-NT index was developed, exhibiting high sensitivity, specificity, and AUC, along with favorable likelihood ratios and repeatability, suggesting that the VAE-NT index is a robust and reliable tool for distinguishing VAE-NT eyes from normal eyes. Further validation in broader populations and over longer follow-up periods is needed to support clinical translation.
Authors
- Lanting Yang (ORCID: https://orcid.org/0000-0003-1362-4827)
- Shihao Chen (ORCID: https://orcid.org/0000-0001-7646-8003)
- Jingyin Zhu
- Hantao Jiang
- Hui Xu (ORCID: https://orcid.org/0009-0003-2994-9834)
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Huadong Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fbioe.2025.1598546
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fudan University