Comorbid hypertension and osteoarthritis exacerbates joint remodeling and gait compensations in female rats with milder effects observed in males
Hypertension worsened OA pathogenesis at the joint level, more substantially affecting joint remodeling and gait compensations in females. Our results encourage further investigation into the pathophysiologic drivers linking hypertension and OA, particularly vascular changes and sex differences.
Authors
- Janak Gaire (ORCID: https://orcid.org/0000-0002-1862-8360)
- Jose Manuel Paz González
- Folly Patterson (ORCID: https://orcid.org/0000-0003-0613-8804)
- Jacob L. Griffith (ORCID: https://orcid.org/0000-0002-8673-6902)
- Kyle D. Allen (ORCID: https://orcid.org/0000-0002-4470-9148)
- Carlos J. Cruz (ORCID: https://orcid.org/0000-0002-7424-9867)
- Angela Philistin
Institutions
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100649
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34