VOSviewer and CiteSpace-Based Knowledge Mapping and Visualization Analysis of the Research Progress on the Homology of Medicine and Food: Traditional Chinese Medicine Mulberry Leaves

目的：对近30年药食同源中药桑叶的相关文献进行分析，探索桑叶研究领域的现状和研究热点，为后续研究提供一定参考。方法：以Web of Science (WOS)与中国知网(CNKI)的数据库为数据源，应用CiteSpace (6.3.R1)、VOSviewer (1.6.20) Zotero、Excel 2019软件分别对桑叶中英文文献的年度发文量、作者、机构、关键词等进行分析，并绘制可视化图谱。结果：共纳入文献1623篇，其中中文文献713篇，英文文献910篇。年度发文量虽有波动但总体仍呈增长的趋势，研究机构以农业和农村事务部、西南大学、中国农业科学院为代表；被引频次的中英文文献的研究方向具有相似性，都涉及桑叶的化学成分和药理作用的研究；中文文献高频关键词为高效液相色谱、黄酮、生物碱、多糖等，英文文献高频关键词为抗氧化活性、氧化应激、肥胖等。结论：桑叶研究主要聚焦于有效成分分离提取、化学成分、药理作用等方向，目前面临提取技术待突破、部分化学成分作用机制不明等问题。此外，将桑叶用于药食两用、功能饲料等行业，推动桑源产业发展，将成为未来研究热点。Objective: By analyzing the relevant literature on mulberry leaves, a traditional Chinese medicine with both food and medicinal properties, over the past 30 years, this study aims to explore the current status and research hotspots in the field of mulberry research, providing a reference for subsequent studies. Methods: Using the databases of Web of Science (WOS) and CNKI (China National Knowledge Infrastructure) as data sources, the annual publication volume, authors, institutions, and keywords of mulberry leaf literature in Chinese and English were analyzed using VOSviewer (1.6.20), CiteSpace (6.3.R1), and Excel 2019 software, and visual maps were drawn. Results: A total of 1623 articles were included, of which 713 were in Chinese and 910 in English. Although there were fluctuations in the annual publication volume, the overall trend was still increasing. The research institutions represented by the Ministry of Agriculture and Rural Affairs, Southwest University, and the Chinese Academy of Agricultural Sciences; The research directions of the frequently cited Chinese and English literature have similarities, both involving the study of the chemical composition and pharmacological effects of mulberry leaves; the high-frequency keywords of Chinese literature are high-performance liquid chromatography, flavonoids, alkaloids, polysaccharides, etc., and the high-frequency keywords of English literature are antioxidant activity, oxidative stress, obesity, etc. Conclusion: The research on mulberry leaves primarily focuses on the separation and extraction of active ingredients, chemical compositions, and pharmacological effects. At present, challenges persist in areas such as the urgent need for breakthroughs in extraction technologies and the unclear mechanisms of action for certain chemical components. In addition, the application of mulberry leaves in industries such as dual-purpose (medicinal and edible) products and functional feed, as well as the promotion of the development of mulberry-derived industries, will become a research hotspot in the future.