Low Dose-Averaged Linear Energy Transfer Contributes to Local Recurrence of Pancreatic Cancer Treated With Carbon Ion Radiation Therapy
This is the largest study investigating the association between tumor LET<sub>d</sub> profiles and LC post-CIRT. The results suggest that low LET<sub>d</sub> within the CTV is associated with poor LC in patients with pancreatic cancer treated with CIRT.
Authors
- Makoto Sakai (ORCID: https://orcid.org/0000-0001-9928-2375)
- Tatsuya Ohno (ORCID: https://orcid.org/0000-0002-6703-3144)
- Yuhei Miyasaka (ORCID: https://orcid.org/0000-0001-5137-1862)
- Takahiro Oike (ORCID: https://orcid.org/0000-0003-1332-4306)
- Narisa Dewi Maulany Darwis (ORCID: https://orcid.org/0009-0004-9953-5765)
- Shintaro Shiba (ORCID: https://orcid.org/0000-0002-1293-4113)
- Kento Tomizawa (ORCID: https://orcid.org/0000-0002-7822-2952)
- Daijiro Kobayashi (ORCID: https://orcid.org/0000-0001-8887-9520)
- Mutsumi Tashiro (ORCID: https://orcid.org/0000-0003-3253-0527)
- Hanae Yoshida
- Masahiko Okamoto (ORCID: https://orcid.org/0000-0002-4107-7448)
- Soichiro Sakamoto
Institutions
- Gunma University (JP)
- Gunma University Hospital (JP)
- Hitachi (Japan) (JP)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.07.1406
- Citations
- 2
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 3.04