Nrf2/UBE3B protects against acute lung injury by inhibiting ferritinophagy through the ubiquitination of NCOA4
This study highlights the role of the Nrf2/UBE3B/NCOA4 axis in AECII ferroptosis and II/R-ALI pathogenesis, suggesting that Nrf2 activation may be a promising strategy for ALI treatment.
Authors
- Beibei Hu (ORCID: https://orcid.org/0000-0001-7317-6873)
- Yunfan Gu (ORCID: https://orcid.org/0009-0005-6074-4743)
- Yanjun Wang (ORCID: https://orcid.org/0009-0001-9975-4376)
- Hong Jiang (ORCID: https://orcid.org/0000-0001-7188-5713)
- Hui Dong (ORCID: https://orcid.org/0000-0001-6236-9805)
- Rong Hu (ORCID: https://orcid.org/0000-0002-6093-9744)
Institutions
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s13062-025-00678-z
- Citations
- 5
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- National Natural Science Foundation of China