FFECTIVENESS OF LIQUID NITROGEN CRYOTHERAPY FOR ALOPECIA AREATA

Introduction: Alopecia areata (AA) is an autoimmune disease causing hair loss, which may adversely affect patients' quality of life. Liquid nitrogen cryotherapy has been suggested as a potential treatment, but its effectiveness is still under investigation. Objective: This study aimed to evaluate the effectiveness of liquid nitrogen cryotherapy in promoting hair regrowth in patients with alopecia areata, comparing it to alternative treatments. Materials and Method:  A randomized controlled trial was conducted at Dermatology Department, Bolan Medical Complex Hospital Quetta, Pakistan from October, 2024 to March, 2025. Sixty patients, diagnosed with mild to moderate AA were randomized into two arms the cryotherapy with liquid nitrogen or non cryotherapy alternatives. Clinical and dermoscopy assessment of the efficacy of hair regrowth was done after six treatment sessions. Results:  The cryotherapy group registered an increment in hair regrowth of 60%, a significant increase from the 40% observed in the other treatment group. The cryotherapy group maintained an increase in visibility of follicular activity when tested by dermoscopy. Conclusion:  Cryotherapy using liquid nitrogen to treat alopecia areata can be very effective, and it can lead to significant regrowth and healthier follicles.