Analysis of Risk Factors and Blood Group Related to Primary Angle-Closure Glaucoma

Objective: To investigate the risk factors and blood type analysis of primary acute angle-closure glaucoma. Methods: A retrospective analysis of 615 patients with primary angle-closure glaucoma admitted to the Affiliated Hospital of Youjiang Medical College for Nationalities from January 2015 to December 2024, and 2696 patients diagnosed with age-related cataract in the same period were used as the control group. The age, gender, family history of glaucoma and blood type distribution characteristics of the two groups were observed. Results: There were 143 male patients in the PACG group, accounting for 23.25% of the total number, and 472 female patients, accounting for 76.75% of the total number, with a male to female ratio of 0.30:1. There were 1204 male patients in the control group, accounting for 44.66% of the total number, and 1492 female patients, accounting for 55.34% of the total number, with a male to female ratio of 0.81:1. The difference between the two groups was statistically significant (P B type (n = 173, 28.13%) > A type (n = 122, 19.84%) > AB type (n = 24, 3.90%). The distribution of ABO blood group in the control group: O type (n = 1320, 48.96%) > B type (n = 708, 26.26%) > A type (n = 533, 19.77%) > AB type (n = 135, 5.01%). The results of single factor analysis showed that there was no significant difference (P > 0.05). Conclusion: Middle-aged and elderly women with a family history of glaucoma are high-risk factors for PACG. Whether blood type is related to the pathogenesis of glaucoma still needs further discussion. We should focus on people with high-risk factors for PACG, and try to achieve early prevention, early detection and early treatment.