Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar
Our study identified candidate genes for cold adaptation in wild boar. The variant rs341219502 in the IGF1R enhancer and the variant rs327139795 in the BRD4 exon, both of which were under positive selection and nearly fixed in populations from cold regions, suggest they may have originated de novo in these populations. Further analysis indicated that rs341219502 could influence enhancer function, while rs327139795 may affect amino acid alterations. Overall, our study highlights the adaptive evolution of genomic molecules that contribute to the remarkable environmental flexibility of wild boar.
Authors
- Jie Zhong (ORCID: https://orcid.org/0000-0003-0354-9448)
- Nhien Tran (ORCID: https://orcid.org/0000-0002-5009-9323)
- Jianhai Chen (ORCID: https://orcid.org/0000-0003-0093-2003)
- Hong Mā (ORCID: https://orcid.org/0000-0001-8717-4422)
- Jianlin Han (ORCID: https://orcid.org/0000-0002-1527-3963)
- Ivan Jakovlić (ORCID: https://orcid.org/0000-0002-2461-3712)
- Shengqian Xia (ORCID: https://orcid.org/0000-0002-9264-3649)
- Yangying Jia
- Shuhong Zhao (ORCID: https://orcid.org/0000-0002-3997-2320)
- Nikica Šprem (ORCID: https://orcid.org/0000-0002-3475-6653)
- Mikhail Sablin (ORCID: https://orcid.org/0000-0002-2773-7454)
- Yapin Guo
- Yunxia Zhao (ORCID: https://orcid.org/0000-0002-2253-2484)
- Hao Yang (ORCID: https://orcid.org/0000-0003-1092-1092)
- Renzuo Kuang
- Zhixiang Xu
- Di Liu (ORCID: https://orcid.org/0000-0003-3693-2726)
Institutions
- University of Zagreb (HR)
- Huazhong Agricultural University (CN)
- Hainan University (CN)
- Sichuan University (CN)
- Zoological Institute (RU)
- University of Chicago (US)
- West China Hospital of Sichuan University (CN)
- National Institute of Animal Sciences (VN)
- Wuhan Institute of Bioengineering (CN)
- Heilongjiang Provincial Academy of Agricultural Sciences (CN)
- Sanya University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Genetics Selection Evolution
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12711-025-00986-y
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Hrvatska Zaklada za Znanost
- National Key Research and Development Program of China
- West China Hospital, Sichuan University