Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation
In conclusion, our study highlights the role of TH signaling via thraa in modulating zebrafish heart regeneration through metabolic regulation, inflammation, cardiac tissue regeneration, and its interplay with hif3a.
Authors
- Wai‐Yee Chan (ORCID: https://orcid.org/0000-0002-9714-0936)
- Wei Ge (ORCID: https://orcid.org/0000-0002-4296-1585)
- Xufeng Qi (ORCID: https://orcid.org/0000-0002-5911-071X)
- Jianmin Sun (ORCID: https://orcid.org/0000-0003-2327-4285)
- Dong Guo (ORCID: https://orcid.org/0000-0001-7057-2838)
- Hui Zhao (ORCID: https://orcid.org/0000-0003-4742-1139)
- Imtiaz Ul Hassan (ORCID: https://orcid.org/0009-0000-8529-2118)
- Chunmei Jiang (ORCID: https://orcid.org/0000-0001-6325-4225)
- Huan Yan (ORCID: https://orcid.org/0000-0002-3734-5913)
- Dongqing Cai (ORCID: https://orcid.org/0000-0002-6014-5362)
- Sheue-yann Cheng (ORCID: https://orcid.org/0000-0003-3530-2386)
- Man Yee Cheung (ORCID: https://orcid.org/0000-0003-1372-131X)
- Hui Wang (ORCID: https://orcid.org/0000-0002-5756-3774)
- Daniel Wuyang Dio
Institutions
- National Institutes of Health (US)
- Jinan University (CN)
- Chinese University of Hong Kong (HK)
- Shanghai Jiao Tong University (CN)
- University of Macau (MO)
- Renji Hospital (CN)
- National Human Genome Research Institute (US)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Ningxia Medical University (CN)
- National Cancer Institute (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12964-025-02350-5
- Citations
- 3
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Research Grants Council, University Grants Committee
- Innovation and Technology Commission