Methodological approach for allele-specific antibody responses to HEK-293T-based cell lines expressing single MHC class I chain-related gene B antigens
While the present study did not detect allele-specific anti-MICB antibody responses, establishing HEK-293T cell lines expressing single MICB antigens represents a significant methodological advance. This platform enables the potential assessment of immune responses targeted to individual MICB allotypes, thus offering new avenues for the future study of MICB immunogenicity in transplantation settings.
Authors
- In‐Cheol Baek (ORCID: https://orcid.org/0000-0003-3630-3364)
- Ji-Ho Jeon (ORCID: https://orcid.org/0000-0003-4091-7772)
- You‐Seok Hyun (ORCID: https://orcid.org/0000-0001-8572-2595)
- Cheol-Hwa Hong (ORCID: https://orcid.org/0000-0003-4220-7432)
- Tai‐Gyu Kim (ORCID: https://orcid.org/0000-0002-2226-2138)
- Eun‐Jee Oh (ORCID: https://orcid.org/0000-0001-5870-915X)
- Hyeyoung Lee (ORCID: https://orcid.org/0000-0001-8871-5091)
Institutions
- Catholic Kwandong University International St. Mary's Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- BMC Molecular and Cell Biology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12860-025-00549-5
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea