Research Progress of Lipoprotein(a) in the Diagnosis and Treatment of Coronary Heart Disease

冠心病对人类健康威胁极大，而血脂异常被认为是冠心病的主要危险因素之一。脂蛋白(a) [LP(a)]是一种特殊的脂蛋白颗粒，LP(a)水平升高可显著增加冠心病发生发展的风险。随着人们对LP(a)研究的深入，LP(a)的代谢途径、致病机制及治疗手段受到广泛关注。本文将对Lp(a)的结构、代谢途径、流行病学、致病机制、与冠心病的相关性及其治疗进行综述。Coronary heart disease represents a substantial threat to human health, with dyslipidemia being one of its primary risk factors. Lipoprotein(a) [LP(a)] is a unique form of lipoprotein particle. High levels of LP(a) are associated with a marked increase in the risk of developing and progressing coronary heart disease. As research on LP(a) advances, its metabolic pathways, disease-causing mechanisms, and therapeutic approaches have garnered significant interest. This paper aims to provide an overview of the structure, metabolism, epidemiology, pathogenic mechanisms, association with coronary heart disease, and treatment strategies for LP(a).