MRI contrast accumulation in features of cerebral small vessel disease: blood-brain barrier dysfunction or elevated vascular density?
Our findings support the notion that contrast leakage across the BBB accumulates within and in proximity of SVD-related lesions. However, high contrast accumulation may mainly reflect high vascularization, and to a lesser degree than previously recognized BBB dysfunction.
Authors
- Anders Eklund (ORCID: https://orcid.org/0000-0002-2031-722X)
- Tomas Vikner (ORCID: https://orcid.org/0000-0003-3181-785X)
- Anders Garpebring (ORCID: https://orcid.org/0000-0002-0532-232X)
- Jan Malm (ORCID: https://orcid.org/0000-0001-6451-1940)
- Anders Wåhlin (ORCID: https://orcid.org/0000-0001-6784-1945)
- Cecilia Björnfot (ORCID: https://orcid.org/0009-0001-8812-8943)
Institutions
- Umeå University (SE)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1186/s12987-025-00675-4
- Citations
- 1
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.36