Revealing age-related changes in the intraocular microenvironment and senescence modulators using aqueous humor proteomics and machine learning
These findings establish a framework for age-related changes in the AH proteome and provide potential senescence biomarkers and therapeutic targets for age-related eye diseases.
Authors
- Shimin Dong (ORCID: https://orcid.org/0000-0002-3741-1335)
- Kun Zeng (ORCID: https://orcid.org/0000-0002-6713-2871)
- Tiansheng Chou (ORCID: https://orcid.org/0000-0003-0255-9054)
- Zongyi Zhan (ORCID: https://orcid.org/0000-0002-6621-1172)
- Xiaosheng Huang (ORCID: https://orcid.org/0000-0002-6375-0816)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-3067-9080)
- Xinhua Liu (ORCID: https://orcid.org/0000-0002-7984-2977)
- Wenqun Xi
- Liangnan Sun
- Shaoyi Mei (ORCID: https://orcid.org/0000-0002-0684-3821)
- Siqi Liu (ORCID: https://orcid.org/0000-0001-9744-3681)
- Yi Liu (ORCID: https://orcid.org/0000-0003-0240-0369)
- Zonghui Yan
Institutions
- BGI Group (China) (CN)
- Central South University (CN)
- Southern University of Science and Technology (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fcell.2025.1583330
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shenzhen Science and Technology Innovation Program
- Basic and Applied Basic Research Foundation of Guangdong Province