Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly
Lower baseline hippocampal z-scores are associated with a greater rate of hippocampal atrophy to the follow-up examination. If validated in larger cohorts, these findings could help establish cut-off values for pathological atrophy in cross-sectional studies.
Authors
- Aurore Menegaux (ORCID: https://orcid.org/0000-0003-3965-0396)
- Pantéleimon Giannakopoulos (ORCID: https://orcid.org/0000-0003-4624-7386)
- Vivian Schultz (ORCID: https://orcid.org/0009-0006-0938-8154)
- François R. Herrmann (ORCID: https://orcid.org/0000-0003-1312-1517)
- Benita Schmitz‐Koep (ORCID: https://orcid.org/0000-0002-8874-5749)
- Marie‐Louise Montandon
- Severin Schramm (ORCID: https://orcid.org/0000-0002-3299-5861)
- Sven Haller (ORCID: https://orcid.org/0000-0001-7433-0203)
- Dennis M. Hedderich (ORCID: https://orcid.org/0000-0001-8994-5593)
- Su Hwan Kim (ORCID: https://orcid.org/0000-0002-5383-2041)
- Christian Sorg
- Melissa Thalhammer (ORCID: https://orcid.org/0000-0003-1950-4340)
- Cristelle Rodriguez (ORCID: https://orcid.org/0000-0001-6073-2455)
- Claus Zimmer (ORCID: https://orcid.org/0000-0002-4805-9103)
Institutions
- University of Geneva (CH)
- Uppsala University (SE)
- Capital Medical University (CN)
- TUM Klinikum (DE)
- Beijing Tian Tan Hospital (CN)
- University Hospital of Geneva (CH)
- Centre d'Imagerie BioMedicale (CH)
- Technical University of Munich (DE)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fnagi.2025.1542857
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Technische Universität München
- Federalno Ministarstvo Obrazovanja i Nauke