Reevaluating anticoagulation therapy for sepsis-associated disseminated intravascular coagulation based on endothelial glycocalyx shedding quantification: a single-center, retrospective, observational pilot study
Syndecan-1 is a potential marker for monitoring endothelial injury and recovery from sepsis-associated DIC. Extended anticoagulant therapy may improve outcomes by reducing endothelial damage and potentially enhancing recovery from DIC in patients with sepsis. Further large-scale studies are required to confirm these findings.
Authors
- Tomoaki Yoshimura (ORCID: https://orcid.org/0009-0008-2486-8169)
- Hideshi Okada (ORCID: https://orcid.org/0000-0002-7775-4308)
- Akio Suzuki (ORCID: https://orcid.org/0000-0003-2106-2123)
- Kodai Suzuki (ORCID: https://orcid.org/0000-0003-1861-7394)
- Keiko Suzuki (ORCID: https://orcid.org/0000-0001-9924-7991)
- Shozo Yoshida (ORCID: https://orcid.org/0000-0002-3778-0560)
- Nobuyuki Tetsuka (ORCID: https://orcid.org/0000-0002-0463-2326)
- Kazuyuki Sumi
Institutions
- Gifu Pharmaceutical University (JP)
- Gifu University Hospital (JP)
- Gifu University (JP)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fmed.2025.1566753
- Citations
- 2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71