Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice
Our findings demonstrate that intraperitoneal binge-like alcohol exposure induces gut dysbiosis in both tumor-prone and wild-type mice. These alterations in the gut microbiome may contribute to the pro-inflammatory and tumor-promoting effects of alcohol in breast tissue. This study provides insights into the potential role of gut dysbiosis in alcohol-induced mammary tumor promotion and offers avenues for future research.
Authors
- Di Hu (ORCID: https://orcid.org/0000-0003-1698-9055)
- Ashutosh K. Mangalam (ORCID: https://orcid.org/0000-0002-9926-2531)
- Honghuang Lin (ORCID: https://orcid.org/0000-0003-3043-3942)
- Ze Zhang (ORCID: https://orcid.org/0000-0001-6164-7930)
- Jia Luo (ORCID: https://orcid.org/0000-0002-6968-3618)
- Luís Meza (ORCID: https://orcid.org/0000-0002-0235-297X)
- Shailesh K. Shahi (ORCID: https://orcid.org/0000-0002-8506-7655)
- Hui Li
- Wen Wen (ORCID: https://orcid.org/0009-0003-1873-7262)
Institutions
- University of Iowa (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fonc.2025.1557040
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health