Comparative transcriptomic and genomic analysis of tumor cells in the marginal and center regions of tumor nests in human hepatocellular carcinoma
Tumor nests exhibit significant transcriptional differentiation along spatial axes: the central regions show high expression of metabolism-related genes, while the marginal regions are enriched in immune-regulatory genes. This pattern is also observed in liver fibrotic nodules. This center-margin functional division may inform rational design of therapeutics that simultaneously modulate metabolism and immune responses.
Authors
- Yufei He
- Yikai Hu
- Zhili He (ORCID: https://orcid.org/0000-0001-8225-7333)
- Huixuan Xu (ORCID: https://orcid.org/0000-0002-9480-416X)
- Ziyi Li (ORCID: https://orcid.org/0000-0003-0947-9137)
- Hongyang Wang (ORCID: https://orcid.org/0000-0002-4709-3334)
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fcell.2025.1611951
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00